| Cape Girardeau to Enumclaw (Washington) | 1,777.65 mi (2,860.86 km) |
| Cape Girardeau to Ephrata (Pennsylvania) | 746.88 mi (1,201.99 km) |
| Cape Girardeau to Erie (Colorado) | 854.85 mi (1,375.75 km) |
| Cape Girardeau to Erie (Pennsylvania) | 603.14 mi (970.66 km) |
| Cape Girardeau to Erlanger (Kentucky) | 294.55 mi (474.04 km) |
| Cape Girardeau to Escanaba (Michigan) | 596.68 mi (960.26 km) |
| Cape Girardeau to Escondido (California) | 1,573.68 mi (2,532.60 km) |
| Cape Girardeau to Española (New Mexico) | 918.31 mi (1,477.88 km) |
| Cape Girardeau to Essex (Maryland) | 723.56 mi (1,164.45 km) |
| Cape Girardeau to Essex Junction (Vermont) | 989.13 mi (1,591.84 km) |
| Cape Girardeau to Estelle (Louisiana) | 516.81 mi (831.72 km) |
| Cape Girardeau to Estero (Florida) | 878.40 mi (1,413.65 km) |
| Cape Girardeau to Euclid (Ohio) | 520.66 mi (837.92 km) |
| Cape Girardeau to Eufaula (Alabama) | 449.43 mi (723.29 km) |
| Cape Girardeau to Eugene (Oregon) | 1,805.29 mi (2,905.33 km) |
