| Cape Girardeau to Euless (Texas) | 524.84 mi (844.65 km) |
| Cape Girardeau to Eureka (California) | 1,859.67 mi (2,992.85 km) |
| Cape Girardeau to Eureka (Missouri) | 101.40 mi (163.18 km) |
| Cape Girardeau to Eustis (Florida) | 740.62 mi (1,191.92 km) |
| Cape Girardeau to Evans (Colorado) | 842.56 mi (1,355.97 km) |
| Cape Girardeau to Evans (Georgia) | 491.48 mi (790.96 km) |
| Cape Girardeau to Evanston (Illinois) | 341.87 mi (550.19 km) |
| Cape Girardeau to Evanston (Wyoming) | 1,173.49 mi (1,888.55 km) |
| Cape Girardeau to Evansville (Indiana) | 120.28 mi (193.57 km) |
| Cape Girardeau to Everett (Massachusetts) | 1,040.11 mi (1,673.90 km) |
| Cape Girardeau to Everett (Washington) | 1,796.00 mi (2,890.38 km) |
| Cape Girardeau to Evergreen Park (Illinois) | 320.40 mi (515.64 km) |
| Cape Girardeau to Ewa Beach (Hawaii) | 4,179.60 mi (6,726.41 km) |
| Cape Girardeau to Ewa Gentry (Hawaii) | 4,180.04 mi (6,727.12 km) |
| Cape Girardeau to Excelsior Springs (Missouri) | 289.76 mi (466.33 km) |
