| Cape Girardeau to Felida (Washington) | 1,795.71 mi (2,889.91 km) |
| Cape Girardeau to Fenton (Michigan) | 488.99 mi (786.95 km) |
| Cape Girardeau to Fergus Falls (Minnesota) | 704.49 mi (1,133.77 km) |
| Cape Girardeau to Ferguson (Missouri) | 107.12 mi (172.39 km) |
| Cape Girardeau to Fernandina Beach (Florida) | 653.05 mi (1,050.99 km) |
| Cape Girardeau to Ferndale (Maryland) | 712.64 mi (1,146.88 km) |
| Cape Girardeau to Ferndale (Michigan) | 492.34 mi (792.34 km) |
| Cape Girardeau to Ferndale (Washington) | 1,828.61 mi (2,942.86 km) |
| Cape Girardeau to Fernley (Nevada) | 1,603.89 mi (2,581.21 km) |
| Cape Girardeau to Ferry Pass (Florida) | 488.40 mi (786.00 km) |
| Cape Girardeau to Festus (Missouri) | 78.07 mi (125.65 km) |
| Cape Girardeau to Fife (Washington) | 1,794.75 mi (2,888.37 km) |
| Cape Girardeau to Fillmore (California) | 1,649.63 mi (2,654.82 km) |
| Cape Girardeau to Findlay (Ohio) | 408.76 mi (657.84 km) |
| Cape Girardeau to Finneytown (Ohio) | 303.65 mi (488.67 km) |
