| Cape Girardeau to Firestone (Colorado) | 851.25 mi (1,369.95 km) |
| Cape Girardeau to Fish Hawk (Florida) | 780.38 mi (1,255.89 km) |
| Cape Girardeau to Fishers (Indiana) | 266.59 mi (429.03 km) |
| Cape Girardeau to Fitchburg (Massachusetts) | 1,005.75 mi (1,618.60 km) |
| Cape Girardeau to Fitchburg (Wisconsin) | 392.17 mi (631.13 km) |
| Cape Girardeau to Five Corners (Washington) | 1,788.96 mi (2,879.05 km) |
| Cape Girardeau to Five Forks (South Carolina) | 444.44 mi (715.26 km) |
| Cape Girardeau to Flagstaff (Arizona) | 1,235.06 mi (1,987.64 km) |
| Cape Girardeau to Flat Rock (Michigan) | 470.03 mi (756.44 km) |
| Cape Girardeau to Fleming Island (Florida) | 671.59 mi (1,080.82 km) |
| Cape Girardeau to Flint (Michigan) | 501.49 mi (807.06 km) |
| Cape Girardeau to Floral Park (New York) | 881.87 mi (1,419.24 km) |
| Cape Girardeau to Florence (Alabama) | 201.40 mi (324.12 km) |
| Cape Girardeau to Florence (Arizona) | 1,265.84 mi (2,037.17 km) |
| Cape Girardeau to Florence (Kentucky) | 290.99 mi (468.30 km) |
