| Cape Girardeau to Florence (South Carolina) | 588.72 mi (947.45 km) |
| Cape Girardeau to Florence-Graham (California) | 1,620.87 mi (2,608.55 km) |
| Cape Girardeau to Florham Park (New Jersey) | 847.01 mi (1,363.12 km) |
| Cape Girardeau to Florida (Puerto Rico) | 1,910.24 mi (3,074.23 km) |
| Cape Girardeau to Florida City (Florida) | 978.66 mi (1,575.00 km) |
| Cape Girardeau to Florida Ridge (Florida) | 858.19 mi (1,381.12 km) |
| Cape Girardeau to Florin (California) | 1,729.48 mi (2,783.33 km) |
| Cape Girardeau to Florissant (Missouri) | 111.00 mi (178.64 km) |
| Cape Girardeau to Flower Hill (Maryland) | 683.26 mi (1,099.60 km) |
| Cape Girardeau to Flower Mound (Texas) | 518.72 mi (834.81 km) |
| Cape Girardeau to Flowing Wells (Arizona) | 1,262.27 mi (2,031.42 km) |
| Cape Girardeau to Foley (Alabama) | 489.80 mi (788.25 km) |
| Cape Girardeau to Folsom (California) | 1,713.86 mi (2,758.20 km) |
| Cape Girardeau to Fond du Lac (Wisconsin) | 450.25 mi (724.61 km) |
| Cape Girardeau to Fontana (California) | 1,575.25 mi (2,535.12 km) |
