| Cape Girardeau to Frederick (Maryland) | 673.49 mi (1,083.88 km) |
| Cape Girardeau to Fredericksburg (Texas) | 722.52 mi (1,162.78 km) |
| Cape Girardeau to Fredericksburg (Virginia) | 662.09 mi (1,065.54 km) |
| Cape Girardeau to Frederickson (Washington) | 1,793.40 mi (2,886.20 km) |
| Cape Girardeau to Freeport (Illinois) | 343.98 mi (553.59 km) |
| Cape Girardeau to Freeport (New York) | 887.09 mi (1,427.63 km) |
| Cape Girardeau to Freeport (Texas) | 668.02 mi (1,075.07 km) |
| Cape Girardeau to Fremont (California) | 1,770.43 mi (2,849.23 km) |
| Cape Girardeau to Fremont (Nebraska) | 466.93 mi (751.46 km) |
| Cape Girardeau to Fremont (Ohio) | 443.23 mi (713.32 km) |
| Cape Girardeau to French Valley (California) | 1,565.74 mi (2,519.82 km) |
| Cape Girardeau to Fresno (California) | 1,660.55 mi (2,672.40 km) |
| Cape Girardeau to Fresno (Texas) | 635.85 mi (1,023.30 km) |
| Cape Girardeau to Fridley (Minnesota) | 570.31 mi (917.83 km) |
| Cape Girardeau to Friendly (Maryland) | 692.15 mi (1,113.91 km) |
