| Cape Girardeau to Friendswood (Texas) | 629.11 mi (1,012.46 km) |
| Cape Girardeau to Frisco (Texas) | 500.12 mi (804.86 km) |
| Cape Girardeau to Front Royal (Virginia) | 627.92 mi (1,010.54 km) |
| Cape Girardeau to Fruit Cove (Florida) | 675.34 mi (1,086.85 km) |
| Cape Girardeau to Fruita (Colorado) | 1,046.24 mi (1,683.76 km) |
| Cape Girardeau to Fruitville (Florida) | 803.77 mi (1,293.54 km) |
| Cape Girardeau to Fuller Heights (Florida) | 783.19 mi (1,260.42 km) |
| Cape Girardeau to Fullerton (California) | 1,605.12 mi (2,583.19 km) |
| Cape Girardeau to Fullerton (Pennsylvania) | 789.15 mi (1,270.02 km) |
| Cape Girardeau to Fulshear (Texas) | 639.66 mi (1,029.43 km) |
| Cape Girardeau to Fulton (Missouri) | 168.20 mi (270.70 km) |
| Cape Girardeau to Fulton (New York) | 805.86 mi (1,296.90 km) |
| Cape Girardeau to Fuquay-Varina (North Carolina) | 610.45 mi (982.42 km) |
| Cape Girardeau to Gadsden (Alabama) | 302.67 mi (487.10 km) |
| Cape Girardeau to Gaffney (South Carolina) | 466.88 mi (751.38 km) |
