| Carlisle to Orbetello | 1,071.56 mi (1,724.52 km) |
| Carlisle to Oria | 1,369.93 mi (2,204.69 km) |
| Carlisle to Oristano | 1,164.03 mi (1,873.32 km) |
| Carlisle to Orta Nova | 1,264.31 mi (2,034.71 km) |
| Carlisle to Orte | 1,102.64 mi (1,774.53 km) |
| Carlisle to Ortona | 1,167.66 mi (1,879.17 km) |
| Carlisle to Orvieto | 1,080.03 mi (1,738.14 km) |
| Carlisle to Orzinuovi | 866.24 mi (1,394.08 km) |
| Carlisle to Osimo | 1,077.16 mi (1,733.52 km) |
| Carlisle to Ospitaletto | 861.66 mi (1,386.70 km) |
| Carlisle to Ostuni | 1,355.44 mi (2,181.38 km) |
| Carlisle to Ottaviano | 1,255.04 mi (2,019.79 km) |
| Carlisle to Ovada | 874.67 mi (1,407.65 km) |
| Carlisle to Ozieri | 1,130.12 mi (1,818.76 km) |
| Carlisle to Paceco | 1,374.81 mi (2,212.55 km) |
