| Carlisle to Sacile | 914.10 mi (1,471.11 km) |
| Carlisle to Sala Consilina | 1,313.65 mi (2,114.11 km) |
| Carlisle to Salemi | 1,391.25 mi (2,238.99 km) |
| Carlisle to Salerno | 1,272.96 mi (2,048.62 km) |
| Carlisle to Salo | 872.69 mi (1,404.46 km) |
| Carlisle to Salsomaggiore Terme | 900.48 mi (1,449.18 km) |
| Carlisle to Saluzzo | 845.35 mi (1,360.46 km) |
| Carlisle to Salzano | 924.51 mi (1,487.86 km) |
| Carlisle to Samarate | 821.79 mi (1,322.54 km) |
| Carlisle to San Benedetto del Tronto | 1,118.71 mi (1,800.39 km) |
| Carlisle to San Biagio di Callalta | 924.81 mi (1,488.33 km) |
| Carlisle to San Bonifacio | 906.01 mi (1,458.08 km) |
| Carlisle to San Casciano in Val di Pesa | 1,000.23 mi (1,609.71 km) |
| Carlisle to San Cataldo | 1,441.58 mi (2,319.99 km) |
| Carlisle to San Cesareo | 1,151.46 mi (1,853.09 km) |
