| Carlisle to Sestu | 1,213.06 mi (1,952.23 km) |
| Carlisle to Settimo Torinese | 823.06 mi (1,324.59 km) |
| Carlisle to Seveso | 830.08 mi (1,335.88 km) |
| Carlisle to Sezze | 1,177.31 mi (1,894.69 km) |
| Carlisle to Siano | 1,264.05 mi (2,034.29 km) |
| Carlisle to Siena | 1,023.71 mi (1,647.51 km) |
| Carlisle to Signa | 990.60 mi (1,594.21 km) |
| Carlisle to Silea | 923.79 mi (1,486.70 km) |
| Carlisle to Silvi Paese | 1,147.98 mi (1,847.50 km) |
| Carlisle to Sinalunga | 1,040.82 mi (1,675.03 km) |
| Carlisle to Siniscola | 1,146.49 mi (1,845.09 km) |
| Carlisle to Sinnai | 1,215.23 mi (1,955.72 km) |
| Carlisle to Siracusa | 1,501.00 mi (2,415.62 km) |
| Carlisle to Solaro | 830.19 mi (1,336.06 km) |
| Carlisle to Soliera | 931.72 mi (1,499.45 km) |
