| Castelo Branco to Sestu | 883.29 mi (1,421.52 km) |
| Castelo Branco to Settimo Torinese | 858.53 mi (1,381.67 km) |
| Castelo Branco to Seveso | 933.05 mi (1,501.60 km) |
| Castelo Branco to Sezze | 1,081.67 mi (1,740.78 km) |
| Castelo Branco to Siano | 1,168.23 mi (1,880.09 km) |
| Castelo Branco to Siena | 1,000.70 mi (1,610.48 km) |
| Castelo Branco to Signa | 994.04 mi (1,599.74 km) |
| Castelo Branco to Silea | 1,079.02 mi (1,736.51 km) |
| Castelo Branco to Silvi Paese | 1,136.60 mi (1,829.19 km) |
| Castelo Branco to Sinalunga | 1,019.89 mi (1,641.36 km) |
| Castelo Branco to Siniscola | 907.63 mi (1,460.69 km) |
| Castelo Branco to Sinnai | 889.16 mi (1,430.97 km) |
| Castelo Branco to Siracusa | 1,244.22 mi (2,002.37 km) |
| Castelo Branco to Solaro | 929.96 mi (1,496.62 km) |
| Castelo Branco to Soliera | 998.71 mi (1,607.27 km) |
