| Chalons-en-Champagne to Sangeorz-Bai | 939.77 mi (1,512.42 km) |
| Chalons-en-Champagne to Sannicolau Mare | 782.48 mi (1,259.29 km) |
| Chalons-en-Champagne to Santana | 815.69 mi (1,312.73 km) |
| Chalons-en-Champagne to Satu Mare | 851.91 mi (1,371.02 km) |
| Chalons-en-Champagne to Scobinti | 1,041.72 mi (1,676.49 km) |
| Chalons-en-Champagne to Scornicesti | 998.80 mi (1,607.41 km) |
| Chalons-en-Champagne to Sebes | 918.08 mi (1,477.50 km) |
| Chalons-en-Champagne to Seini | 870.47 mi (1,400.88 km) |
| Chalons-en-Champagne to Sfantu-Gheorghe | 1,020.58 mi (1,642.47 km) |
| Chalons-en-Champagne to Sibiu | 948.34 mi (1,526.20 km) |
| Chalons-en-Champagne to Sighetu Marmatiei | 895.36 mi (1,440.94 km) |
| Chalons-en-Champagne to Sighisoara | 967.41 mi (1,556.90 km) |
| Chalons-en-Champagne to Simeria | 895.46 mi (1,441.11 km) |
| Chalons-en-Champagne to Sinaia | 1,022.50 mi (1,645.55 km) |
| Chalons-en-Champagne to Slatina | 994.62 mi (1,600.69 km) |
