| Crewe to Sacile | 828.99 mi (1,334.14 km) |
| Crewe to Sala Consilina | 1,217.75 mi (1,959.78 km) |
| Crewe to Salemi | 1,282.78 mi (2,064.43 km) |
| Crewe to Salerno | 1,175.46 mi (1,891.72 km) |
| Crewe to Salo | 778.54 mi (1,252.94 km) |
| Crewe to Salsomaggiore Terme | 801.03 mi (1,289.14 km) |
| Crewe to Saluzzo | 736.70 mi (1,185.60 km) |
| Crewe to Salzano | 835.84 mi (1,345.16 km) |
| Crewe to Samarate | 721.15 mi (1,160.58 km) |
| Crewe to San Benedetto del Tronto | 1,025.46 mi (1,650.31 km) |
| Crewe to San Biagio di Callalta | 837.84 mi (1,348.37 km) |
| Crewe to San Bonifacio | 813.70 mi (1,309.52 km) |
| Crewe to San Casciano in Val di Pesa | 900.75 mi (1,449.62 km) |
| Crewe to San Cataldo | 1,335.32 mi (2,148.99 km) |
| Crewe to San Cesareo | 1,051.40 mi (1,692.06 km) |
