| Miami (Florida) to Humacao | 1,061.00 mi (1,707.52 km) |
| Tampa (Florida) to Humacao | 1,254.48 mi (2,018.88 km) |
| Atlanta (Georgia) to Humacao | 1,575.53 mi (2,535.57 km) |
| Washington (District of Columbia) to Humacao | 1,583.66 mi (2,548.65 km) |
| Baltimore (Maryland) to Humacao | 1,598.19 mi (2,572.03 km) |
| Philadelphia (Pennsylvania) to Humacao | 1,609.04 mi (2,589.50 km) |
| Brooklyn (New York) to Humacao | 1,627.78 mi (2,619.66 km) |
| New York (New York) to Humacao | 1,630.22 mi (2,623.59 km) |
| Queens (New York) to Humacao | 1,631.63 mi (2,625.85 km) |
| Boston (Massachusetts) to Humacao | 1,698.20 mi (2,732.99 km) |
| Detroit (Michigan) to Humacao | 1,957.59 mi (3,150.44 km) |
| Houston (Texas) to Humacao | 2,024.54 mi (3,258.19 km) |
| St. Louis (Missouri) to Humacao | 2,038.36 mi (3,280.42 km) |
| Chicago (Illinois) to Humacao | 2,082.24 mi (3,351.04 km) |
| Dallas (Texas) to Humacao | 2,167.50 mi (3,488.25 km) |
| Minneapolis (Minnesota) to Humacao | 2,434.37 mi (3,917.73 km) |
| Denver (Colorado) to Humacao | 2,761.03 mi (4,443.45 km) |
| Phoenix (Arizona) to Humacao | 3,038.75 mi (4,890.40 km) |
| Las Vegas (Nevada) to Humacao | 3,244.74 mi (5,221.90 km) |
| San Diego (California) to Humacao | 3,321.89 mi (5,346.07 km) |
| Riverside (California) to Humacao | 3,344.31 mi (5,382.15 km) |
| Los Angeles (California) to Humacao | 3,403.12 mi (5,476.79 km) |
| San Francisco (California) to Humacao | 3,650.85 mi (5,875.47 km) |
| Portland (Oregon) to Humacao | 3,737.27 mi (6,014.56 km) |
| Seattle (Washington) to Humacao | 3,751.45 mi (6,037.38 km) |
