| Des Moines to Dallas (Texas) | 630.83 mi (1,015.23 km) |
| Des Moines to Atlanta (Georgia) | 736.49 mi (1,185.27 km) |
| Des Moines to Houston (Texas) | 820.40 mi (1,320.31 km) |
| Des Moines to Washington (District of Columbia) | 892.93 mi (1,437.03 km) |
| Des Moines to Baltimore (Maryland) | 905.85 mi (1,457.83 km) |
| Des Moines to Philadelphia (Pennsylvania) | 970.68 mi (1,562.15 km) |
| Des Moines to Brooklyn (New York) | 1,023.26 mi (1,646.77 km) |
| Des Moines to New York (New York) | 1,024.01 mi (1,647.98 km) |
| Des Moines to Queens (New York) | 1,029.92 mi (1,657.50 km) |
| Des Moines to Tampa (Florida) | 1,129.86 mi (1,818.33 km) |
| Des Moines to Phoenix (Arizona) | 1,149.62 mi (1,850.13 km) |
| Des Moines to Boston (Massachusetts) | 1,155.35 mi (1,859.35 km) |
| Des Moines to Las Vegas (Nevada) | 1,217.59 mi (1,959.52 km) |
| Des Moines to Miami (Florida) | 1,331.93 mi (2,143.53 km) |
| Des Moines to Riverside (California) | 1,396.50 mi (2,247.44 km) |
| Des Moines to San Diego (California) | 1,421.79 mi (2,288.14 km) |
| Des Moines to Los Angeles (California) | 1,441.49 mi (2,319.85 km) |
| Des Moines to Seattle (Washington) | 1,463.67 mi (2,355.56 km) |
| Des Moines to Portland (Oregon) | 1,471.26 mi (2,367.76 km) |
| Des Moines to San Francisco (California) | 1,548.70 mi (2,492.39 km) |
| Des Moines to Minneapolis (Minnesota) | 234.93 mi (378.08 km) |
| Des Moines to St. Louis (Missouri) | 269.77 mi (434.15 km) |
| Des Moines to Chicago (Illinois) | 306.06 mi (492.56 km) |
| Des Moines to Detroit (Michigan) | 542.29 mi (872.73 km) |
| Des Moines to Denver (Colorado) | 603.02 mi (970.47 km) |
