| Destin to Delaware (Ohio) | 709.48 mi (1,141.79 km) |
| Destin to Delhi (California) | 2,014.31 mi (3,241.73 km) |
| Destin to Delray Beach (Florida) | 473.53 mi (762.07 km) |
| Destin to Deltona (Florida) | 331.95 mi (534.22 km) |
| Destin to Deming (New Mexico) | 1,260.61 mi (2,028.75 km) |
| Destin to Denison (Texas) | 635.74 mi (1,023.12 km) |
| Destin to Dent (Ohio) | 616.35 mi (991.93 km) |
| Destin to Denton (Texas) | 655.89 mi (1,055.56 km) |
| Destin to Dentsville (South Carolina) | 410.45 mi (660.55 km) |
| Destin to Denver (Colorado) | 1,221.83 mi (1,966.35 km) |
| Destin to Depew (New York) | 964.97 mi (1,552.96 km) |
| Destin to Derby (Connecticut) | 1,061.66 mi (1,708.57 km) |
| Destin to Derby (Kansas) | 790.70 mi (1,272.51 km) |
| Destin to Des Moines (Iowa) | 868.58 mi (1,397.84 km) |
| Destin to Des Moines (Washington) | 2,228.28 mi (3,586.08 km) |
