| Destin to Des Plaines (Illinois) | 808.12 mi (1,300.55 km) |
| Destin to Desert Hot Springs (California) | 1,769.45 mi (2,847.66 km) |
| Destin to DeSoto (Texas) | 630.66 mi (1,014.94 km) |
| Destin to Destrehan (Louisiana) | 234.69 mi (377.69 km) |
| Destin to Detroit (Michigan) | 849.03 mi (1,366.39 km) |
| Destin to Diamond Bar (California) | 1,842.36 mi (2,964.99 km) |
| Destin to Diamond Springs (California) | 2,025.01 mi (3,258.94 km) |
| Destin to Dickinson (North Dakota) | 1,434.33 mi (2,308.32 km) |
| Destin to Dickinson (Texas) | 518.27 mi (834.07 km) |
| Destin to Dickson (Tennessee) | 395.07 mi (635.81 km) |
| Destin to Difficult Run (Virginia) | 782.92 mi (1,259.98 km) |
| Destin to Dinuba (California) | 1,934.86 mi (3,113.86 km) |
| Destin to Discovery Bay (California) | 2,061.42 mi (3,317.53 km) |
| Destin to Dix Hills (New York) | 1,028.05 mi (1,654.49 km) |
| Destin to Dixon (California) | 2,076.48 mi (3,341.77 km) |
