| Destin to Eau Claire (Wisconsin) | 1,033.35 mi (1,663.02 km) |
| Destin to Echelon (New Jersey) | 918.84 mi (1,478.73 km) |
| Destin to Eden (North Carolina) | 572.87 mi (921.95 km) |
| Destin to Eden Prairie (Minnesota) | 1,068.36 mi (1,719.36 km) |
| Destin to Edgewater (Florida) | 346.39 mi (557.47 km) |
| Destin to Edgewater (New Jersey) | 1,003.89 mi (1,615.61 km) |
| Destin to Edgewood (Maryland) | 847.99 mi (1,364.70 km) |
| Destin to Edgewood (Washington) | 2,223.29 mi (3,578.04 km) |
| Destin to Edina (Minnesota) | 1,069.17 mi (1,720.66 km) |
| Destin to Edinburg (Texas) | 763.98 mi (1,229.51 km) |
| Destin to Edmond (Oklahoma) | 730.61 mi (1,175.80 km) |
| Destin to Edmonds (Washington) | 2,239.45 mi (3,604.04 km) |
| Destin to Edwards (Colorado) | 1,301.97 mi (2,095.32 km) |
| Destin to Edwardsville (Illinois) | 613.57 mi (987.44 km) |
| Destin to Effingham (Illinois) | 614.28 mi (988.59 km) |
