| Destin to Emeryville (California) | 2,098.90 mi (3,377.86 km) |
| Destin to Emmaus (Pennsylvania) | 932.32 mi (1,500.42 km) |
| Destin to Emporia (Kansas) | 782.27 mi (1,258.95 km) |
| Destin to Encinitas (California) | 1,812.43 mi (2,916.83 km) |
| Destin to Endicott (New York) | 993.32 mi (1,598.59 km) |
| Destin to Endwell (New York) | 995.77 mi (1,602.53 km) |
| Destin to Englewood (Colorado) | 1,224.00 mi (1,969.83 km) |
| Destin to Englewood (Florida) | 343.80 mi (553.30 km) |
| Destin to Englewood (New Jersey) | 1,007.05 mi (1,620.70 km) |
| Destin to Englewood (Ohio) | 665.52 mi (1,071.05 km) |
| Destin to Enid (Oklahoma) | 776.89 mi (1,250.28 km) |
| Destin to Ennis (Texas) | 614.09 mi (988.29 km) |
| Destin to Ensley (Florida) | 48.68 mi (78.35 km) |
| Destin to Enterprise (Alabama) | 74.30 mi (119.57 km) |
| Destin to Enterprise (Nevada) | 1,700.56 mi (2,736.79 km) |
