| Destin to Enumclaw (Washington) | 2,209.60 mi (3,556.01 km) |
| Destin to Ephrata (Pennsylvania) | 889.69 mi (1,431.82 km) |
| Destin to Erie (Colorado) | 1,238.21 mi (1,992.71 km) |
| Destin to Erie (Pennsylvania) | 884.16 mi (1,422.92 km) |
| Destin to Erlanger (Kentucky) | 604.80 mi (973.33 km) |
| Destin to Escanaba (Michigan) | 1,061.30 mi (1,707.99 km) |
| Destin to Escondido (California) | 1,801.27 mi (2,898.86 km) |
| Destin to Española (New Mexico) | 1,194.98 mi (1,923.13 km) |
| Destin to Essex (Maryland) | 836.67 mi (1,346.49 km) |
| Destin to Essex Junction (Vermont) | 1,215.26 mi (1,955.78 km) |
| Destin to Estelle (Louisiana) | 220.36 mi (354.63 km) |
| Destin to Estero (Florida) | 394.70 mi (635.21 km) |
| Destin to Euclid (Ohio) | 821.16 mi (1,321.53 km) |
| Destin to Eufaula (Alabama) | 130.57 mi (210.13 km) |
| Destin to Eugene (Oregon) | 2,202.57 mi (3,544.69 km) |
