| Destin to Friendswood (Texas) | 525.92 mi (846.39 km) |
| Destin to Frisco (Texas) | 636.90 mi (1,025.00 km) |
| Destin to Front Royal (Virginia) | 753.71 mi (1,212.98 km) |
| Destin to Fruit Cove (Florida) | 290.35 mi (467.27 km) |
| Destin to Fruita (Colorado) | 1,395.76 mi (2,246.26 km) |
| Destin to Fruitville (Florida) | 321.81 mi (517.91 km) |
| Destin to Fuller Heights (Florida) | 319.32 mi (513.90 km) |
| Destin to Fullerton (California) | 1,848.92 mi (2,975.55 km) |
| Destin to Fullerton (Pennsylvania) | 937.56 mi (1,508.85 km) |
| Destin to Fulshear (Texas) | 564.75 mi (908.88 km) |
| Destin to Fulton (Missouri) | 662.07 mi (1,065.50 km) |
| Destin to Fulton (New York) | 1,049.88 mi (1,689.62 km) |
| Destin to Fuquay-Varina (North Carolina) | 572.20 mi (920.86 km) |
| Destin to Gadsden (Alabama) | 251.08 mi (404.08 km) |
| Destin to Gaffney (South Carolina) | 427.47 mi (687.94 km) |
