| Destin to Hutchinson (Minnesota) | 1,089.33 mi (1,753.10 km) |
| Destin to Hutto (Texas) | 659.29 mi (1,061.03 km) |
| Destin to Hyattsville (Maryland) | 800.67 mi (1,288.56 km) |
| Destin to Hybla Valley (Virginia) | 785.47 mi (1,264.08 km) |
| Destin to Idaho Falls (Idaho) | 1,666.13 mi (2,681.38 km) |
| Destin to Idylwood (Virginia) | 787.65 mi (1,267.59 km) |
| Destin to Ilchester (Maryland) | 820.31 mi (1,320.17 km) |
| Destin to Immokalee (Florida) | 411.27 mi (661.88 km) |
| Destin to Imperial (California) | 1,715.20 mi (2,760.34 km) |
| Destin to Imperial Beach (California) | 1,805.90 mi (2,906.32 km) |
| Destin to Independence (Kentucky) | 601.11 mi (967.39 km) |
| Destin to Independence (Missouri) | 748.20 mi (1,204.11 km) |
| Destin to Indian Trail (North Carolina) | 467.74 mi (752.75 km) |
| Destin to Indiana (Pennsylvania) | 816.92 mi (1,314.71 km) |
| Destin to Indianapolis (Indiana) | 648.50 mi (1,043.66 km) |
