| Destin to Indianola (Iowa) | 854.83 mi (1,375.72 km) |
| Destin to Indio (California) | 1,751.90 mi (2,819.40 km) |
| Destin to Inglewood (California) | 1,872.68 mi (3,013.79 km) |
| Destin to Inkster (Michigan) | 840.48 mi (1,352.62 km) |
| Destin to Inver Grove Heights (Minnesota) | 1,059.30 mi (1,704.78 km) |
| Destin to Inwood (New York) | 1,003.46 mi (1,614.92 km) |
| Destin to Iona (Florida) | 383.18 mi (616.66 km) |
| Destin to Ionia (Michigan) | 872.76 mi (1,404.57 km) |
| Destin to Iowa City (Iowa) | 827.43 mi (1,331.61 km) |
| Destin to Irmo (South Carolina) | 400.62 mi (644.74 km) |
| Destin to Irondale (Alabama) | 217.85 mi (350.60 km) |
| Destin to Ironton (Ohio) | 602.15 mi (969.06 km) |
| Destin to Irvine (California) | 1,840.43 mi (2,961.88 km) |
| Destin to Irving (Texas) | 640.43 mi (1,030.67 km) |
| Destin to Isabela (Puerto Rico) | 1,469.93 mi (2,365.63 km) |
