| Destin to Iselin (New Jersey) | 978.79 mi (1,575.21 km) |
| Destin to Isla Vista (California) | 1,958.66 mi (3,152.16 km) |
| Destin to Issaquah (Washington) | 2,219.88 mi (3,572.54 km) |
| Destin to Ithaca (New York) | 998.45 mi (1,606.85 km) |
| Destin to Ives Estates (Florida) | 490.12 mi (788.77 km) |
| Destin to Jackson (Michigan) | 826.59 mi (1,330.27 km) |
| Destin to Jackson (Mississippi) | 257.59 mi (414.56 km) |
| Destin to Jackson (Missouri) | 515.83 mi (830.14 km) |
| Destin to Jackson (Tennessee) | 388.29 mi (624.89 km) |
| Destin to Jackson (Wyoming) | 1,608.46 mi (2,588.56 km) |
| Destin to Jacksonville (Alabama) | 239.56 mi (385.53 km) |
| Destin to Jacksonville (Arkansas) | 452.07 mi (727.54 km) |
| Destin to Jacksonville (Florida) | 285.88 mi (460.08 km) |
| Destin to Jacksonville (Illinois) | 678.92 mi (1,092.62 km) |
| Destin to Jacksonville (North Carolina) | 607.07 mi (976.98 km) |
