| Detroit to Edegem | 3,937.74 mi (6,337.18 km) |
| Detroit to Eeklo | 3,902.71 mi (6,280.80 km) |
| Detroit to Eghezee | 3,974.37 mi (6,396.14 km) |
| Detroit to Ekeren | 3,932.10 mi (6,328.11 km) |
| Detroit to Enghien | 3,936.54 mi (6,335.25 km) |
| Detroit to Erquelinnes | 3,952.82 mi (6,361.45 km) |
| Detroit to Ertvelde | 3,909.87 mi (6,292.33 km) |
| Detroit to Esneux | 4,000.98 mi (6,438.95 km) |
| Detroit to Essen | 3,928.01 mi (6,321.53 km) |
| Detroit to Estaimpuis | 3,908.10 mi (6,289.48 km) |
| Detroit to Etterbeek | 3,945.61 mi (6,349.84 km) |
| Detroit to Eupen | 4,015.40 mi (6,462.16 km) |
| Detroit to Evere | 3,945.15 mi (6,349.10 km) |
| Detroit to Evergem | 3,913.39 mi (6,298.00 km) |
| Detroit to Farciennes | 3,965.25 mi (6,381.45 km) |
