| Detroit to Sacile | 4,438.99 mi (7,143.86 km) |
| Detroit to Sala Consilina | 4,795.33 mi (7,717.34 km) |
| Detroit to Salemi | 4,788.89 mi (7,706.98 km) |
| Detroit to Salerno | 4,748.73 mi (7,642.35 km) |
| Detroit to Salo | 4,375.70 mi (7,042.01 km) |
| Detroit to Salsomaggiore Terme | 4,384.15 mi (7,055.62 km) |
| Detroit to Saluzzo | 4,289.24 mi (6,902.87 km) |
| Detroit to Salzano | 4,441.20 mi (7,147.41 km) |
| Detroit to Samarate | 4,304.90 mi (6,928.07 km) |
| Detroit to San Benedetto del Tronto | 4,617.16 mi (7,430.60 km) |
| Detroit to San Biagio di Callalta | 4,445.52 mi (7,154.37 km) |
| Detroit to San Bonifacio | 4,413.44 mi (7,102.74 km) |
| Detroit to San Casciano in Val di Pesa | 4,478.95 mi (7,208.17 km) |
| Detroit to San Cataldo | 4,853.87 mi (7,811.55 km) |
| Detroit to San Cesareo | 4,620.19 mi (7,435.47 km) |
