| Detroit to Santa Venerina | 4,894.05 mi (7,876.22 km) |
| Detroit to Santeramo in Colle | 4,825.55 mi (7,765.97 km) |
| Detroit to Santo Stefano di Magra | 4,407.12 mi (7,092.57 km) |
| Detroit to Santo Stino di Livenza | 4,455.52 mi (7,170.46 km) |
| Detroit to Sarezzo | 4,360.45 mi (7,017.47 km) |
| Detroit to Sarno | 4,737.04 mi (7,623.52 km) |
| Detroit to Saronno | 4,314.78 mi (6,943.97 km) |
| Detroit to Sarzana | 4,410.87 mi (7,098.61 km) |
| Detroit to Sassari | 4,486.87 mi (7,220.92 km) |
| Detroit to Sasso Marconi | 4,451.81 mi (7,164.50 km) |
| Detroit to Sassuolo | 4,427.05 mi (7,124.65 km) |
| Detroit to Sava | 4,875.51 mi (7,846.37 km) |
| Detroit to Saviano | 4,728.66 mi (7,610.04 km) |
| Detroit to Savigliano | 4,294.93 mi (6,912.02 km) |
| Detroit to Savignano sul Panaro | 4,439.76 mi (7,145.10 km) |
