| Detroit to Selargius | 4,572.24 mi (7,358.30 km) |
| Detroit to Selvazzano Dentro | 4,433.97 mi (7,135.78 km) |
| Detroit to Senago | 4,320.27 mi (6,952.81 km) |
| Detroit to Senigallia | 4,558.81 mi (7,336.69 km) |
| Detroit to Seravezza | 4,426.49 mi (7,123.75 km) |
| Detroit to Seregno | 4,320.40 mi (6,953.01 km) |
| Detroit to Seriate | 4,339.83 mi (6,984.28 km) |
| Detroit to Sermoneta | 4,638.84 mi (7,465.49 km) |
| Detroit to Serramanna | 4,555.04 mi (7,330.62 km) |
| Detroit to Serravalle Pistoiese | 4,454.89 mi (7,169.45 km) |
| Detroit to Sessa Aurunca | 4,691.24 mi (7,549.83 km) |
| Detroit to Sesto Calende | 4,294.42 mi (6,911.20 km) |
| Detroit to Sesto Fiorentino | 4,472.45 mi (7,197.71 km) |
| Detroit to Sesto San Giovanni | 4,326.22 mi (6,962.37 km) |
| Detroit to Sestri Levante | 4,381.49 mi (7,051.32 km) |
