| Detroit to Spello | 4,566.52 mi (7,349.10 km) |
| Detroit to Spilamberto | 4,437.10 mi (7,140.83 km) |
| Detroit to Spilimbergo | 4,447.59 mi (7,157.70 km) |
| Detroit to Spinea | 4,444.53 mi (7,152.79 km) |
| Detroit to Spoleto | 4,576.62 mi (7,365.36 km) |
| Detroit to Spoltore | 4,648.23 mi (7,480.60 km) |
| Detroit to Spresiano | 4,436.48 mi (7,139.83 km) |
| Detroit to Squinzano | 4,893.59 mi (7,875.47 km) |
| Detroit to Statte | 4,853.33 mi (7,810.68 km) |
| Detroit to Stezzano | 4,338.53 mi (6,982.20 km) |
| Detroit to Strada | 4,487.23 mi (7,221.50 km) |
| Detroit to Stradella | 4,346.24 mi (6,994.60 km) |
| Detroit to Striano | 4,734.98 mi (7,620.21 km) |
| Detroit to Subiaco | 4,627.66 mi (7,447.50 km) |
| Detroit to Sulmona | 4,656.64 mi (7,494.13 km) |
