| Detroit to Ede | 3,954.02 mi (6,363.38 km) |
| Detroit to Eemnes | 3,931.91 mi (6,327.79 km) |
| Detroit to Eerbeek | 3,966.96 mi (6,384.21 km) |
| Detroit to Eersel | 3,964.06 mi (6,379.54 km) |
| Detroit to Eijsden | 3,998.11 mi (6,434.34 km) |
| Detroit to Eindhoven | 3,967.59 mi (6,385.21 km) |
| Detroit to Elburg | 3,947.64 mi (6,353.11 km) |
| Detroit to Emmeloord | 3,935.46 mi (6,333.50 km) |
| Detroit to Emmen | 3,975.24 mi (6,397.53 km) |
| Detroit to Enkhuizen | 3,919.12 mi (6,307.22 km) |
| Detroit to Enschede | 3,994.25 mi (6,428.12 km) |
| Detroit to Epe | 3,955.88 mi (6,366.37 km) |
| Detroit to Ermelo | 3,943.92 mi (6,347.12 km) |
| Detroit to Etten-Leur | 3,931.06 mi (6,326.43 km) |
| Detroit to Franeker | 3,911.54 mi (6,295.02 km) |
