| Difficult Run to Sanary-sur-Mer | 4,159.31 mi (6,693.76 km) |
| Difficult Run to Sannois | 3,837.01 mi (6,175.07 km) |
| Difficult Run to Saran | 3,847.42 mi (6,191.83 km) |
| Difficult Run to Sarcelles | 3,841.59 mi (6,182.43 km) |
| Difficult Run to Sarlat-la-Caneda | 3,901.01 mi (6,278.08 km) |
| Difficult Run to Sarrebourg | 4,043.76 mi (6,507.80 km) |
| Difficult Run to Sarreguemines | 4,033.60 mi (6,491.46 km) |
| Difficult Run to Sartrouville | 3,833.97 mi (6,170.18 km) |
| Difficult Run to Sarzeau | 3,656.33 mi (5,884.30 km) |
| Difficult Run to Sassenage | 4,088.93 mi (6,580.49 km) |
| Difficult Run to Saumur | 3,780.65 mi (6,084.38 km) |
| Difficult Run to Savenay | 3,696.60 mi (5,949.10 km) |
| Difficult Run to Saverne | 4,056.30 mi (6,527.98 km) |
| Difficult Run to Savigny-le-Temple | 3,860.80 mi (6,213.36 km) |
| Difficult Run to Savigny-sur-Orge | 3,848.27 mi (6,193.18 km) |
