| Difficult Run to Sceaux | 3,843.38 mi (6,185.32 km) |
| Difficult Run to Schiltigheim | 4,076.25 mi (6,560.09 km) |
| Difficult Run to Scionzier | 4,101.65 mi (6,600.96 km) |
| Difficult Run to Seclin | 3,829.07 mi (6,162.29 km) |
| Difficult Run to Sedan | 3,929.50 mi (6,323.92 km) |
| Difficult Run to Selestat | 4,074.25 mi (6,556.86 km) |
| Difficult Run to Sene | 3,655.58 mi (5,883.09 km) |
| Difficult Run to Senlis | 3,844.79 mi (6,187.59 km) |
| Difficult Run to Sens | 3,900.90 mi (6,277.89 km) |
| Difficult Run to Septemes-les-Vallons | 4,131.00 mi (6,648.20 km) |
| Difficult Run to Serris | 3,862.25 mi (6,215.69 km) |
| Difficult Run to Sete | 4,055.71 mi (6,527.03 km) |
| Difficult Run to Sevran | 3,849.61 mi (6,195.35 km) |
| Difficult Run to Sevres | 3,838.88 mi (6,178.08 km) |
| Difficult Run to Seynod | 4,087.10 mi (6,577.55 km) |
