| Difficult Run to Seysses | 3,944.79 mi (6,348.52 km) |
| Difficult Run to Sin-le-Noble | 3,837.16 mi (6,175.31 km) |
| Difficult Run to Six-Fours-les-Plages | 4,160.68 mi (6,695.97 km) |
| Difficult Run to Soissons | 3,871.05 mi (6,229.85 km) |
| Difficult Run to Soisy-sous-Montmorency | 3,838.37 mi (6,177.26 km) |
| Difficult Run to Sollies-Pont | 4,167.80 mi (6,707.42 km) |
| Difficult Run to Somain | 3,844.16 mi (6,186.57 km) |
| Difficult Run to Sorgues | 4,090.18 mi (6,582.50 km) |
| Difficult Run to Sotteville-les-Rouen | 3,776.91 mi (6,078.35 km) |
| Difficult Run to Soyaux | 3,835.01 mi (6,171.86 km) |
| Difficult Run to Stains | 3,842.86 mi (6,184.49 km) |
| Difficult Run to Stiring-Wendel | 4,025.24 mi (6,477.99 km) |
| Difficult Run to Strasbourg | 4,076.80 mi (6,560.97 km) |
| Difficult Run to Sucy-en-Brie | 3,853.41 mi (6,201.46 km) |
| Difficult Run to Suresnes | 3,838.04 mi (6,176.73 km) |
