| Difficult Run to Edegem | 3,871.48 mi (6,230.55 km) |
| Difficult Run to Eeklo | 3,834.85 mi (6,171.60 km) |
| Difficult Run to Eghezee | 3,905.06 mi (6,284.58 km) |
| Difficult Run to Ekeren | 3,866.74 mi (6,222.91 km) |
| Difficult Run to Enghien | 3,866.16 mi (6,221.98 km) |
| Difficult Run to Erquelinnes | 3,879.83 mi (6,243.99 km) |
| Difficult Run to Ertvelde | 3,842.34 mi (6,183.64 km) |
| Difficult Run to Esneux | 3,932.72 mi (6,329.11 km) |
| Difficult Run to Essen | 3,864.07 mi (6,218.63 km) |
| Difficult Run to Estaimpuis | 3,835.94 mi (6,173.35 km) |
| Difficult Run to Etterbeek | 3,876.93 mi (6,239.31 km) |
| Difficult Run to Eupen | 3,948.88 mi (6,355.11 km) |
| Difficult Run to Evere | 3,876.74 mi (6,239.02 km) |
| Difficult Run to Evergem | 3,844.59 mi (6,187.28 km) |
| Difficult Run to Farciennes | 3,894.05 mi (6,266.86 km) |
