| Difficult Run to Senftenberg | 4,236.19 mi (6,817.48 km) |
| Difficult Run to Siegburg | 3,991.31 mi (6,423.39 km) |
| Difficult Run to Siegen | 4,021.42 mi (6,471.85 km) |
| Difficult Run to Sigmaringen | 4,152.54 mi (6,682.87 km) |
| Difficult Run to Simbach am Inn | 4,302.26 mi (6,923.82 km) |
| Difficult Run to Simmerath | 3,960.53 mi (6,373.85 km) |
| Difficult Run to Sindelfingen | 4,124.68 mi (6,638.03 km) |
| Difficult Run to Sinsheim | 4,103.70 mi (6,604.27 km) |
| Difficult Run to Sinzheim | 4,088.89 mi (6,580.43 km) |
| Difficult Run to Sinzig | 4,000.34 mi (6,437.93 km) |
| Difficult Run to Soest | 4,005.78 mi (6,446.68 km) |
| Difficult Run to Solingen | 3,976.40 mi (6,399.40 km) |
| Difficult Run to Soltau | 4,032.81 mi (6,490.17 km) |
| Difficult Run to Sommerda | 4,135.39 mi (6,655.27 km) |
| Difficult Run to Sondershausen | 4,119.49 mi (6,629.68 km) |
