| Difficult Run to Sonneberg | 4,162.03 mi (6,698.14 km) |
| Difficult Run to Sonsbeck | 3,936.42 mi (6,335.05 km) |
| Difficult Run to Sonthofen | 4,214.43 mi (6,782.47 km) |
| Difficult Run to Spaichingen | 4,133.05 mi (6,651.51 km) |
| Difficult Run to Spelle | 3,958.88 mi (6,371.19 km) |
| Difficult Run to Spenge | 4,004.75 mi (6,445.02 km) |
| Difficult Run to Speyer | 4,083.23 mi (6,571.33 km) |
| Difficult Run to Spiesen-Elversberg | 4,030.27 mi (6,486.09 km) |
| Difficult Run to Spremberg | 4,248.23 mi (6,836.87 km) |
| Difficult Run to Springe | 4,043.69 mi (6,507.68 km) |
| Difficult Run to Sprockhovel | 3,977.53 mi (6,401.22 km) |
| Difficult Run to Stade | 4,002.10 mi (6,440.76 km) |
| Difficult Run to Stadtallendorf | 4,062.55 mi (6,538.05 km) |
| Difficult Run to Stadthagen | 4,027.40 mi (6,481.47 km) |
| Difficult Run to Stadtlohn | 3,947.38 mi (6,352.69 km) |
