| Difficult Run to Ascoli Piceno | 4,512.01 mi (7,261.38 km) |
| Difficult Run to Asola | 4,294.33 mi (6,911.05 km) |
| Difficult Run to Asolo | 4,338.69 mi (6,982.45 km) |
| Difficult Run to Assemini | 4,432.45 mi (7,133.34 km) |
| Difficult Run to Assisi | 4,462.08 mi (7,181.02 km) |
| Difficult Run to Asti | 4,209.26 mi (6,774.15 km) |
| Difficult Run to Atessa | 4,577.94 mi (7,367.48 km) |
| Difficult Run to Atri | 4,538.93 mi (7,304.70 km) |
| Difficult Run to Atripalda | 4,636.65 mi (7,461.96 km) |
| Difficult Run to Augusta | 4,792.69 mi (7,713.09 km) |
| Difficult Run to Aulla | 4,307.92 mi (6,932.92 km) |
| Difficult Run to Aurisina | 4,417.89 mi (7,109.90 km) |
| Difficult Run to Avellino | 4,635.03 mi (7,459.36 km) |
| Difficult Run to Aversa | 4,607.19 mi (7,414.56 km) |
| Difficult Run to Avezzano | 4,534.70 mi (7,297.90 km) |
