| Difficult Run to Castelletto sopra Ticino | 4,201.78 mi (6,762.11 km) |
| Difficult Run to Castelli Calepio | 4,258.64 mi (6,853.63 km) |
| Difficult Run to Castelnovo ne' Monti | 4,319.51 mi (6,951.59 km) |
| Difficult Run to Castelnuovo Berardenga | 4,404.19 mi (7,087.85 km) |
| Difficult Run to Castelnuovo di Porto | 4,490.15 mi (7,226.19 km) |
| Difficult Run to Castelnuovo di Verona | 4,302.14 mi (6,923.63 km) |
| Difficult Run to Castelnuovo Rangone | 4,338.63 mi (6,982.36 km) |
| Difficult Run to Castelvetrano | 4,665.11 mi (7,507.77 km) |
| Difficult Run to Castelvetro di Modena | 4,341.03 mi (6,986.21 km) |
| Difficult Run to Castenaso | 4,363.10 mi (7,021.74 km) |
| Difficult Run to Castenedolo | 4,280.88 mi (6,889.41 km) |
| Difficult Run to Castiglion Fiorentino | 4,422.36 mi (7,117.09 km) |
| Difficult Run to Castiglione del Lago | 4,435.08 mi (7,137.58 km) |
| Difficult Run to Castiglione delle Stiviere | 4,291.86 mi (6,907.08 km) |
| Difficult Run to Castrolibero | 4,757.78 mi (7,656.90 km) |
