| Difficult Run to Cervignano del Friuli | 4,397.45 mi (7,077.02 km) |
| Difficult Run to Cesa | 4,608.66 mi (7,416.93 km) |
| Difficult Run to Cesano Maderno | 4,226.47 mi (6,801.85 km) |
| Difficult Run to Cesena | 4,409.01 mi (7,095.62 km) |
| Difficult Run to Cesenatico | 4,413.36 mi (7,102.61 km) |
| Difficult Run to Cetraro | 4,739.66 mi (7,627.74 km) |
| Difficult Run to Cherasco | 4,202.39 mi (6,763.09 km) |
| Difficult Run to Chiampo | 4,320.24 mi (6,952.76 km) |
| Difficult Run to Chiaravalle | 4,474.63 mi (7,201.21 km) |
| Difficult Run to Chiari | 4,261.61 mi (6,858.40 km) |
| Difficult Run to Chiavari | 4,277.07 mi (6,883.29 km) |
| Difficult Run to Chieri | 4,188.94 mi (6,741.46 km) |
| Difficult Run to Chieti | 4,555.32 mi (7,331.08 km) |
| Difficult Run to Chioggia | 4,373.56 mi (7,038.57 km) |
| Difficult Run to Chiusi | 4,435.05 mi (7,137.53 km) |
