| Difficult Run to Cutrofiano | 4,815.06 mi (7,749.09 km) |
| Difficult Run to Dalmine | 4,245.29 mi (6,832.14 km) |
| Difficult Run to Deruta | 4,456.58 mi (7,172.17 km) |
| Difficult Run to Desenzano del Garda | 4,291.09 mi (6,905.85 km) |
| Difficult Run to Desio | 4,229.96 mi (6,807.47 km) |
| Difficult Run to Dolianova | 4,437.41 mi (7,141.33 km) |
| Difficult Run to Dolo | 4,357.92 mi (7,013.40 km) |
| Difficult Run to Domodossola | 4,174.58 mi (6,718.34 km) |
| Difficult Run to Dorgali | 4,423.80 mi (7,119.41 km) |
| Difficult Run to Dueville | 4,328.77 mi (6,966.49 km) |
| Difficult Run to Eboli | 4,657.97 mi (7,496.28 km) |
| Difficult Run to Elmas | 4,435.34 mi (7,137.99 km) |
| Difficult Run to Empoli | 4,367.44 mi (7,028.71 km) |
| Difficult Run to Enna | 4,737.71 mi (7,624.60 km) |
| Difficult Run to Eraclea | 4,378.29 mi (7,046.18 km) |
