| Difficult Run to Erba | 4,223.57 mi (6,797.19 km) |
| Difficult Run to Erchie | 4,782.42 mi (7,696.56 km) |
| Difficult Run to Ercolano | 4,619.96 mi (7,435.10 km) |
| Difficult Run to Erice | 4,642.47 mi (7,471.33 km) |
| Difficult Run to Este | 4,347.10 mi (6,995.99 km) |
| Difficult Run to Fabriano | 4,466.02 mi (7,187.37 km) |
| Difficult Run to Faenza | 4,388.46 mi (7,062.54 km) |
| Difficult Run to Fagnano Olona | 4,213.37 mi (6,780.76 km) |
| Difficult Run to Fano | 4,452.82 mi (7,166.12 km) |
| Difficult Run to Fara in Sabina | 4,497.44 mi (7,237.94 km) |
| Difficult Run to Farra di Soligo | 4,344.32 mi (6,991.51 km) |
| Difficult Run to Fasano | 4,751.06 mi (7,646.10 km) |
| Difficult Run to Favara | 4,718.84 mi (7,594.23 km) |
| Difficult Run to Felino | 4,304.06 mi (6,926.72 km) |
| Difficult Run to Feltre | 4,331.11 mi (6,970.25 km) |
