| Difficult Run to Ferentino | 4,539.23 mi (7,305.18 km) |
| Difficult Run to Fermo | 4,506.67 mi (7,252.79 km) |
| Difficult Run to Ferrandina | 4,723.72 mi (7,602.10 km) |
| Difficult Run to Ferrara | 4,358.44 mi (7,014.23 km) |
| Difficult Run to Fiano Romano | 4,493.36 mi (7,231.37 km) |
| Difficult Run to Ficarazzi | 4,681.09 mi (7,533.48 km) |
| Difficult Run to Fidenza | 4,290.80 mi (6,905.38 km) |
| Difficult Run to Fiesole | 4,379.22 mi (7,047.67 km) |
| Difficult Run to Figline Valdarno | 4,393.31 mi (7,070.35 km) |
| Difficult Run to Filottrano | 4,481.22 mi (7,211.83 km) |
| Difficult Run to Finale Emilia | 4,344.17 mi (6,991.26 km) |
| Difficult Run to Finale Ligure | 4,238.60 mi (6,821.36 km) |
| Difficult Run to Fino Mornasco | 4,217.86 mi (6,787.99 km) |
| Difficult Run to Fiorano Modenese | 4,334.17 mi (6,975.17 km) |
| Difficult Run to Fiorenzuola d'Arda | 4,281.44 mi (6,890.30 km) |
