| Difficult Run to Fisciano | 4,641.08 mi (7,469.09 km) |
| Difficult Run to Fiuggi | 4,533.57 mi (7,296.07 km) |
| Difficult Run to Fiume Veneto | 4,368.52 mi (7,030.45 km) |
| Difficult Run to Fiumefreddo di Sicilia | 4,770.83 mi (7,677.90 km) |
| Difficult Run to Fiumicino | 4,491.36 mi (7,228.14 km) |
| Difficult Run to Flero | 4,275.23 mi (6,880.32 km) |
| Difficult Run to Florence | 4,378.80 mi (7,047.00 km) |
| Difficult Run to Floridia | 4,796.05 mi (7,718.50 km) |
| Difficult Run to Foggia | 4,647.92 mi (7,480.11 km) |
| Difficult Run to Foiano della Chiana | 4,421.15 mi (7,115.16 km) |
| Difficult Run to Folignano | 4,515.37 mi (7,266.79 km) |
| Difficult Run to Foligno | 4,470.08 mi (7,193.91 km) |
| Difficult Run to Follonica | 4,386.33 mi (7,059.12 km) |
| Difficult Run to Fondi | 4,558.61 mi (7,336.37 km) |
| Difficult Run to Fontanafredda | 4,360.41 mi (7,017.40 km) |
