| Difficult Run to Imola | 4,378.91 mi (7,047.17 km) |
| Difficult Run to Impruneta | 4,381.62 mi (7,051.53 km) |
| Difficult Run to Induno Olona | 4,206.13 mi (6,769.11 km) |
| Difficult Run to Inverigo | 4,226.24 mi (6,801.47 km) |
| Difficult Run to Inveruno | 4,217.42 mi (6,787.29 km) |
| Difficult Run to Inzago | 4,244.06 mi (6,830.15 km) |
| Difficult Run to Iseo | 4,264.38 mi (6,862.85 km) |
| Difficult Run to Isernia | 4,585.66 mi (7,379.90 km) |
| Difficult Run to Isola Capo Rizzuto | 4,811.40 mi (7,743.21 km) |
| Difficult Run to Isola del Liri | 4,553.58 mi (7,328.28 km) |
| Difficult Run to Isola della Scala | 4,317.97 mi (6,949.10 km) |
| Difficult Run to Isola Vicentina | 4,324.54 mi (6,959.67 km) |
| Difficult Run to Ispica | 4,796.13 mi (7,718.62 km) |
| Difficult Run to Istrana | 4,350.34 mi (7,001.19 km) |
| Difficult Run to Itri | 4,566.17 mi (7,348.55 km) |
