| Difficult Run to Massarosa | 4,335.53 mi (6,977.36 km) |
| Difficult Run to Matelica | 4,472.74 mi (7,198.18 km) |
| Difficult Run to Matera | 4,723.97 mi (7,602.49 km) |
| Difficult Run to Matino | 4,815.40 mi (7,749.63 km) |
| Difficult Run to Mazzarino | 4,744.22 mi (7,635.08 km) |
| Difficult Run to Meda | 4,226.22 mi (6,801.45 km) |
| Difficult Run to Medesano | 4,297.51 mi (6,916.18 km) |
| Difficult Run to Medicina | 4,370.99 mi (7,034.43 km) |
| Difficult Run to Meldola | 4,400.84 mi (7,082.47 km) |
| Difficult Run to Melegnano | 4,242.84 mi (6,828.18 km) |
| Difficult Run to Melendugno | 4,815.03 mi (7,749.04 km) |
| Difficult Run to Melfi | 4,669.78 mi (7,515.29 km) |
| Difficult Run to Melilli | 4,790.68 mi (7,709.86 km) |
| Difficult Run to Melito di Napoli | 4,610.50 mi (7,419.88 km) |
| Difficult Run to Melito di Porto Salvo | 4,792.80 mi (7,713.27 km) |
