| Difficult Run to Melzo | 4,242.28 mi (6,827.29 km) |
| Difficult Run to Mendicino | 4,759.59 mi (7,659.83 km) |
| Difficult Run to Menfi | 4,676.01 mi (7,525.30 km) |
| Difficult Run to Mentana | 4,500.88 mi (7,243.47 km) |
| Difficult Run to Merano | 4,278.18 mi (6,885.07 km) |
| Difficult Run to Merate | 4,236.56 mi (6,818.09 km) |
| Difficult Run to Mercato San Severino | 4,638.99 mi (7,465.74 km) |
| Difficult Run to Mercogliano | 4,632.76 mi (7,455.71 km) |
| Difficult Run to Mesagne | 4,780.17 mi (7,692.95 km) |
| Difficult Run to Messina | 4,771.80 mi (7,679.48 km) |
| Difficult Run to Mestre | 4,362.66 mi (7,021.02 km) |
| Difficult Run to Mestrino | 4,344.08 mi (6,991.12 km) |
| Difficult Run to Milan | 4,233.62 mi (6,813.35 km) |
| Difficult Run to Milazzo | 4,756.57 mi (7,654.95 km) |
| Difficult Run to Minerbio | 4,359.51 mi (7,015.95 km) |
