| Difficult Run to Poggibonsi | 4,384.65 mi (7,056.41 km) |
| Difficult Run to Poggio a Caiano | 4,369.12 mi (7,031.42 km) |
| Difficult Run to Poggio Renatico | 4,355.03 mi (7,008.75 km) |
| Difficult Run to Poggiomarino | 4,628.80 mi (7,449.34 km) |
| Difficult Run to Poirino | 4,192.95 mi (6,747.90 km) |
| Difficult Run to Policoro | 4,744.67 mi (7,635.81 km) |
| Difficult Run to Polistena | 4,786.98 mi (7,703.90 km) |
| Difficult Run to Pomezia | 4,506.71 mi (7,252.85 km) |
| Difficult Run to Pomigliano d'Arco | 4,617.87 mi (7,431.74 km) |
| Difficult Run to Pompei | 4,628.44 mi (7,448.75 km) |
| Difficult Run to Ponsacco | 4,357.02 mi (7,011.94 km) |
| Difficult Run to Pontassieve | 4,386.63 mi (7,059.60 km) |
| Difficult Run to Ponte Buggianese | 4,354.43 mi (7,007.78 km) |
| Difficult Run to Ponte San Pietro | 4,243.25 mi (6,828.85 km) |
| Difficult Run to Pontecorvo | 4,565.60 mi (7,347.62 km) |
