| Difficult Run to Rende | 4,756.40 mi (7,654.68 km) |
| Difficult Run to Resana | 4,345.68 mi (6,993.70 km) |
| Difficult Run to Rescaldina | 4,218.53 mi (6,789.07 km) |
| Difficult Run to Rezzato | 4,280.31 mi (6,888.49 km) |
| Difficult Run to Rho | 4,224.77 mi (6,799.11 km) |
| Difficult Run to Ribera | 4,693.71 mi (7,553.80 km) |
| Difficult Run to Riccione Marina | 4,431.25 mi (7,131.41 km) |
| Difficult Run to Riesi | 4,739.49 mi (7,627.48 km) |
| Difficult Run to Rieti | 4,496.20 mi (7,235.93 km) |
| Difficult Run to Rignano Flaminio | 4,487.05 mi (7,221.21 km) |
| Difficult Run to Rignano sull'Arno | 4,388.96 mi (7,063.35 km) |
| Difficult Run to Rimini | 4,425.68 mi (7,122.45 km) |
| Difficult Run to Rionero in Vulture | 4,673.63 mi (7,521.49 km) |
| Difficult Run to Riposto | 4,773.38 mi (7,682.01 km) |
| Difficult Run to Riva del Garda | 4,290.88 mi (6,905.50 km) |
