| Difficult Run to Sacile | 4,357.61 mi (7,012.90 km) |
| Difficult Run to Sala Consilina | 4,690.09 mi (7,547.97 km) |
| Difficult Run to Salemi | 4,660.46 mi (7,500.28 km) |
| Difficult Run to Salerno | 4,642.49 mi (7,471.37 km) |
| Difficult Run to Salo | 4,286.72 mi (6,898.81 km) |
| Difficult Run to Salsomaggiore Terme | 4,288.75 mi (6,902.08 km) |
| Difficult Run to Saluzzo | 4,186.10 mi (6,736.88 km) |
| Difficult Run to Salzano | 4,356.09 mi (7,010.45 km) |
| Difficult Run to Samarate | 4,211.38 mi (6,777.56 km) |
| Difficult Run to San Benedetto del Tronto | 4,521.44 mi (7,276.55 km) |
| Difficult Run to San Biagio di Callalta | 4,362.08 mi (7,020.09 km) |
| Difficult Run to San Bonifacio | 4,325.23 mi (6,960.78 km) |
| Difficult Run to San Casciano in Val di Pesa | 4,379.73 mi (7,048.49 km) |
| Difficult Run to San Cataldo | 4,727.32 mi (7,607.89 km) |
| Difficult Run to San Cesareo | 4,514.61 mi (7,265.57 km) |
