| Difficult Run to San Vendemiano | 4,353.39 mi (7,006.10 km) |
| Difficult Run to San Vito al Tagliamento | 4,375.23 mi (7,041.26 km) |
| Difficult Run to San Vito dei Normanni | 4,772.55 mi (7,680.68 km) |
| Difficult Run to Sannicandro di Bari | 4,720.04 mi (7,596.16 km) |
| Difficult Run to Sannicandro Garganico | 4,635.11 mi (7,459.49 km) |
| Difficult Run to Sansepolcro | 4,424.11 mi (7,119.92 km) |
| Difficult Run to Sant'Agata de' Goti | 4,615.81 mi (7,428.43 km) |
| Difficult Run to Sant'Agata di Militello | 4,734.85 mi (7,620.01 km) |
| Difficult Run to Sant'Agnello | 4,628.45 mi (7,448.77 km) |
| Difficult Run to Sant'Ambrogio di Valpolicella | 4,302.21 mi (6,923.74 km) |
| Difficult Run to Sant'Anastasia | 4,619.71 mi (7,434.70 km) |
| Difficult Run to Sant'Angelo Lodigiano | 4,250.39 mi (6,840.35 km) |
| Difficult Run to Sant'Antimo | 4,609.63 mi (7,418.48 km) |
| Difficult Run to Sant'Antioco | 4,414.77 mi (7,104.89 km) |
| Difficult Run to Sant'Antonio Abate | 4,631.27 mi (7,453.30 km) |
